Shillong Science Centre was set-up in Shillong by the National Council for Science Museums (NCSM), Kolkata in collaboration with the State Government. The Centre was handed-over to the State Government in February, 2006. The day-to-day management of the Centre is being looked after by the Governing Council of the Centre, which has been registered as an autonomous society of the State Government. 

The Centre is characterised by two channels of communication, i.e., exhibits and activities. While the exhibits, both indoor and outdoor, are mostly interactive, the demonstrations and training programmes are also fully participatory. These activities help children and adults alike to learn the basics of science through fun and enjoyment.

Lately, an Innovation Hub and a Space Education Centre has also been set-up in the Centre on June, 2019 to demonstrate the effectiveness of the application of technologies, innovative ideas and astronomy.